Epigenetics At A Glance
Click on any image below to find out more about the innovator and their contributions/research towards the promising field of epigenetics!
Founded in 2005, Epigentrek specializes in epigenetic kits, antibodies, reagents, and services for epigenetic research in DNA methylation, histone modification, and chromatin studies.
Epigentek's objectives:
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Assist researchers in solving challenges in epigenetic issues.
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Develop and introduce simplification and accuracy to epigenetic experiments.
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Ensure customer satisfaction through superior reliability, speed, service, and quality.
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Encourage and facilitate the study of epigenetics for potential medical applications.
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Pioneer and innovate epigenetic products through routine analysis of technological trends (18)


(1) Introducing the trigger dsRNA
A “trigger“ dsRNA is introduced into the cell’s cytoplasm. (26)
(2) Generating siRNA pool
The Dicer enzyme (and associated co-factors) processes the trigger dsRNA, forming a pool of small interfering RNAs (siRNAs): these are approx. 21 base pairs in length, including 2 nucleotide overhangs at both 3’ ends. (26)
(3) Capturing and unwinding siRNA by RISC
The processed siRNAs are then delivered to an Argonaut-containing RNA-Induced Silencing Complex (RISC), which unwinds the two siRNA strands, retaining one strand to act as a RISC-targeting co-factor. (26)
(4) Binding siRNA-associated RISC to target mRNA
The siRNA’s bound strand confers sequence-based specificity to its associated RISC complex, allowing recognition and base-pairing with the complementary target mRNA. (26)
(5) Destruction of the target mRNA
The RISC complex contains an endonuclease activity, now ascribed to the Argonaut subunit, which causes a single-site cleavage of the target mRNA approximately in the middle of the siRNA binding region. The resulting fragments of target mRNA are thereby destabilized and subsequently get fully degraded through natural endogenous mechanisms. (26)
For more information on the MCGD 290 molecules and its clinical status click here